Adding to the controversy surrounding the potential benefits and risks of wine consumption comes still another study, this time from the University of Kentucky described in the January 2009 issue of Clinical Cancer Research.  The study exposed leukemic cells in cultures to doses of grape seed extract.  After 24 hours of what they called the most effective dosage, 76% of the cells self destructed (a process known as apoptosis).  The presumed cause of the apoptosis was the activation of a protein called JNK which, in turn, may be responsible for regulating the cell life cycle. As with many studies, the results here may or may not be clinically applicable outside of the “petri dish.”  As well, it is unclear if the results would be similar if one was ingesting wine.  The results, however, continue to add intrigue regarding the potential benefits of the antioxidant resveratrol and anthocyanidins, a class of plant chemical compounds that lends grapes its color and defense from disease. There continues to exist controversy over whether wine consumption, even in moderate doses, is beneficial or harmful.  Conflicting studies have lent an air of confusion and uncertainty of late, many study results pointing to potential benefits of responsible wine consumption while others hinting at risks.  It is likely that additional controversial and perhaps conflicting studies will emerge as scientists seek to resolve these issues.  

Tags: anthocyanidins, antioxidant, grape seed extract, Resveratrol, wine consumption